BDBM50007170 Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL26533
SMILES: COc1ccccc1N1CCN(CCCCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1
InChI Key: InChIKey=PRZPXKIXNNNNCD-DJICYOIISA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lausanne Curated by ChEMBL | Assay Description Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement | J Med Chem 39: 126-34 (1996) Article DOI: 10.1021/jm950410b BindingDB Entry DOI: 10.7270/Q2VX0K7V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor of rat hippocampus using [3H]-8-hydroxy-2-(di-n-propylamine) tetralin (8-OH-DPAT) as a radio... | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity of the compound towards D2-dopaminergic receptor using [3H]-NMSP as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]DOB as | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards alpha-1 adrenergic receptor of rat frontal cortex using [3H]- WB- 4101 as a radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 225 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 1C receptor using [3H]-mesulergine as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 1D receptor using [3H]-5-HT as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1B/1D receptor (Rattus norvegicus (Rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 890 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 1B receptor using [3H]-5-HT as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (RAT) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity of the compound towards Dopamine receptor D1 using [3H]-SCH-23,390 as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity of the compound towards 5-hydroxytryptamine 3 receptor using [3H]-GR-65,630 as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor beta (Rattus norvegicus (Rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards beta adrenergic receptor using [3H]DHA as radioligand | J Med Chem 34: 2633-8 (1991) BindingDB Entry DOI: 10.7270/Q2833R0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50007170 (Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Inhibition of binding of [125I]-8-OH-PIPAT ligand to 5-hydroxytryptamine 1A receptor of rat hippocampal homogenates | J Med Chem 37: 1406-7 (1994) BindingDB Entry DOI: 10.7270/Q29Z95JQ | |||||||||||
More data for this Ligand-Target Pair |