BindingDB PrimarySearch

null

SMILES: OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F

InChI Key: InChIKey=MEAQCLPMSVEOQF-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50019040
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-retinol from human recombinant RBP4 by scintillation proximity assay				Bioorg Med Chem Lett 24: 2885-91 (2014) Article DOI: 10.1016/j.bmcl.2014.04.089 BindingDB Entry DOI: 10.7270/Q2154JMV
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis				Bioorg Med Chem Lett 24: 2885-91 (2014) Article DOI: 10.1016/j.bmcl.2014.04.089 BindingDB Entry DOI: 10.7270/Q2154JMV
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.155	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research Curated by ChEMBL					Assay Description Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...				J Med Chem 57: 7731-57 (2014) Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT
Albany Molecular Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research Curated by ChEMBL					Assay Description Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity assay				J Med Chem 57: 7731-57 (2014) Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT
Albany Molecular Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research Curated by ChEMBL					Assay Description Inhibition of CYP2C9 (unknown origin)				J Med Chem 57: 7731-57 (2014) Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT
Albany Molecular Research Curated by ChEMBL					More data for this Ligand-Target Pair
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Albany College of Pharmacy and Health Sciences Curated by ChEMBL					Assay Description Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysis				J Med Chem 62: 5470-5500 (2019) Article DOI: 10.1021/acs.jmedchem.9b00352
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				J Med Chem 57: 7731-57 (2014) Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT
Albany Molecular Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research Curated by ChEMBL					Assay Description Inhibition of CYP3A4 (unknown origin)				J Med Chem 57: 7731-57 (2014) Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT
Albany Molecular Research Curated by ChEMBL					More data for this Ligand-Target Pair
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay				J Med Chem 58: 5863-88 (2015) BindingDB Entry DOI: 10.7270/Q20Z751F
Columbia University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Retinol-binding protein 4 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University Medical Center Curated by ChEMBL					Assay Description Inhibition of retinol-induced interaction of bacterially expressed MBP-tagged RBP4 (unknown origin) with Eu3+ cryptate labeled TTR by HTRF assay				J Med Chem 58: 5863-88 (2015) BindingDB Entry DOI: 10.7270/Q20Z751F
Columbia University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50019040 (CHEMBL1230001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research Curated by ChEMBL					Assay Description Inhibition of CYP2C19 (unknown origin)				J Med Chem 57: 7731-57 (2014) Article DOI: 10.1021/jm5010013 BindingDB Entry DOI: 10.7270/Q2FB54JT
Albany Molecular Research Curated by ChEMBL					More data for this Ligand-Target Pair