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BDBM50020221 (-)-5-hydroxy-2-(dipropylamino)tetralin::(-)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol::5-hydroxy-2-(dipropylamino)tetralin::6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol::6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol (DP-5-ADTN)::CHEMBL273273
SMILES: CCCN(CCC)C1CCc2c(O)cccc2C1
InChI Key: InChIKey=MDBWEQVKJDMEMK-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description In vitro binding affinity of the compound is the ability to displace [3H]-spiperone from human Dopamine receptor D3 expressed in CHO-K1 cells. | J Med Chem 38: 3132-7 (1995) BindingDB Entry DOI: 10.7270/Q28W3C9S | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested in vitro for the inhibition of [3H]-raclopride binding to Dopamine receptor D2 in rat striatum | Bioorg Med Chem Lett 7: 2759-2764 (1997) Article DOI: 10.1016/S0960-894X(97)10068-3 BindingDB Entry DOI: 10.7270/Q2F47P56 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Rattus norvegicus (Rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from rat D3 receptor expressed in HEK293 cells | Bioorg Med Chem 18: 5661-74 (2010) Article DOI: 10.1016/j.bmc.2010.06.025 BindingDB Entry DOI: 10.7270/Q2W37WJ9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from cloned dopamine D3 receptor expressed in HEK cells | J Med Chem 53: 2114-25 (2010) Article DOI: 10.1021/jm901618d BindingDB Entry DOI: 10.7270/Q20K28QZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D3 receptor expressed in HEK293 cells | J Med Chem 53: 1023-37 (2010) Article DOI: 10.1021/jm901184n BindingDB Entry DOI: 10.7270/Q29023VM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Rattus norvegicus (Rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in HEK293 cells | Bioorg Med Chem 17: 3923-33 (2009) Article DOI: 10.1016/j.bmc.2009.04.031 BindingDB Entry DOI: 10.7270/Q25H7G8C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Rattus norvegicus (Rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from rat D3 dopamine receptor expressed in HEK293 cell membranes after 1 hr | Bioorg Med Chem 24: 5088-5102 (2016) Article DOI: 10.1016/j.bmc.2016.08.021 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested in vitro for the inhibition of [3H]-U-86,170 binding to Dopamine receptor D3, expressed in cloned CHO cells | Bioorg Med Chem Lett 7: 2759-2764 (1997) Article DOI: 10.1016/S0960-894X(97)10068-3 BindingDB Entry DOI: 10.7270/Q2F47P56 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description In vitro binding affinity of the compound is the ability to displace [3H]-N-0437 from human Dopamine receptor D2 expressed in CHO-K1 cells | J Med Chem 38: 3132-7 (1995) BindingDB Entry DOI: 10.7270/Q28W3C9S | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinaregatan Curated by ChEMBL | Assay Description Binding affinity against dopamine receptor D2 in rat brain tissue using [3H]spiperone | J Med Chem 36: 3409-16 (1993) BindingDB Entry DOI: 10.7270/Q2X067NP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description In vitro binding affinity of the compound is the ability to displace [3H]-spiperone from human Dopamine receptor D2 expressed in CHO-K1 cells | J Med Chem 38: 3132-7 (1995) BindingDB Entry DOI: 10.7270/Q28W3C9S | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 58.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from rat dopamine D2L receptor expressed in HEK293 cells | Bioorg Med Chem 17: 3923-33 (2009) Article DOI: 10.1016/j.bmc.2009.04.031 BindingDB Entry DOI: 10.7270/Q25H7G8C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 58.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from human dopamine D2L receptor expressed in HEK293 cells | J Med Chem 53: 1023-37 (2010) Article DOI: 10.1021/jm901184n BindingDB Entry DOI: 10.7270/Q29023VM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 58.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from rat D2 receptor expressed in HEK293 cells | Bioorg Med Chem 18: 5661-74 (2010) Article DOI: 10.1016/j.bmc.2010.06.025 BindingDB Entry DOI: 10.7270/Q2W37WJ9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 153 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from rat D2L dopamine receptor expressed in HEK293 cell membranes after 1 hr | Bioorg Med Chem 24: 5088-5102 (2016) Article DOI: 10.1016/j.bmc.2016.08.021 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | 344 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested in vitro for the inhibition of [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor, expressed in cloned CHO cells. | Bioorg Med Chem Lett 7: 2759-2764 (1997) Article DOI: 10.1016/S0960-894X(97)10068-3 BindingDB Entry DOI: 10.7270/Q2F47P56 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 466 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania Curated by ChEMBL | Assay Description Binding affinity to 5-HT7 receptor (unknown origin) | J Med Chem 61: 8475-8503 (2018) Article DOI: 10.1021/acs.jmedchem.7b01898 BindingDB Entry DOI: 10.7270/Q2V98BPM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinaregatan Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor in homogenated rat brain tissue, using by [3H]8-OH-DPAT as radioligand | J Med Chem 36: 3409-16 (1993) BindingDB Entry DOI: 10.7270/Q2X067NP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding | Bioorg Med Chem 17: 3923-33 (2009) Article DOI: 10.1016/j.bmc.2009.04.031 BindingDB Entry DOI: 10.7270/Q25H7G8C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description 50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes | J Med Chem 27: 495-503 (1984) BindingDB Entry DOI: 10.7270/Q24B31WH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
State University of Groningen Curated by ChEMBL | Assay Description Potency to displace the specific in vitro binding of [3H]-N-0437 to calf striatal membrane | J Med Chem 31: 2178-82 (1988) BindingDB Entry DOI: 10.7270/Q22R3S82 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | Bioorg Med Chem 17: 3923-33 (2009) Article DOI: 10.1016/j.bmc.2009.04.031 BindingDB Entry DOI: 10.7270/Q25H7G8C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
State University of Groningen Curated by ChEMBL | Assay Description Potency to displace the specific in vitro binding of [3H]DP-5,6-ADTN to rat striatal membrane | J Med Chem 31: 2178-82 (1988) BindingDB Entry DOI: 10.7270/Q22R3S82 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 41.2 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding | J Med Chem 53: 1023-37 (2010) Article DOI: 10.1021/jm901184n BindingDB Entry DOI: 10.7270/Q29023VM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.23 | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding | J Med Chem 53: 1023-37 (2010) Article DOI: 10.1021/jm901184n BindingDB Entry DOI: 10.7270/Q29023VM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(d...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membr... | J Med Chem 27: 495-503 (1984) BindingDB Entry DOI: 10.7270/Q24B31WH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
