BDBM50031853 ((3E,7E)-4,8,12-Trimethyl-1-phosphono-trideca-3,7,11-trienyl)-phosphonic acid::(2E,6E)-farnesylbisphosphonate::2E,6E-farnesyl bisphosphonate::CHEMBL86513
SMILES: [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]\[#6]=[#6](/P([#8])([#8])=O)P([#8])([#8])=O
InChI Key: InChIKey=GCIMOAWUDYGORG-NTEUORMPSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Squalene synthetase (Rattus norvegicus) | BDBM50031853 (((3E,7E)-4,8,12-Trimethyl-1-phosphono-trideca-3,7,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 32.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers-Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition rat liver microsomal squalene synthase | J Med Chem 38: 2596-605 (1995) BindingDB Entry DOI: 10.7270/Q2BV7FNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl Diphosphate Synthase (GGPPS) (Homo sapiens (Human)) | BDBM50031853 (((3E,7E)-4,8,12-Trimethyl-1-phosphono-trideca-3,7,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of GST-tagged human recombinant GGDPS expressed in BL21 gold bacteria | Bioorg Med Chem 16: 390-9 (2008) Article DOI: 10.1016/j.bmc.2007.09.029 BindingDB Entry DOI: 10.7270/Q26M37PP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl Diphosphate Synthase (GGPPS) (Homo sapiens (Human)) | BDBM50031853 (((3E,7E)-4,8,12-Trimethyl-1-phosphono-trideca-3,7,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria | Bioorg Med Chem 16: 3652-60 (2008) Article DOI: 10.1016/j.bmc.2008.02.016 BindingDB Entry DOI: 10.7270/Q2TB17RN | |||||||||||
More data for this Ligand-Target Pair |