BDBM50032362 3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid methyl ester::5-Ethyl-3-(3-fluoro-2'-isopentyloxycarbonylsulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazole-4-carboxylic acid methyl ester(EXP408)::CHEMBL294512::isopentyloxy 2-{2-[3-flouoro-4-(4-ethyl-5-methyloxycarbonyl-2-propyl-1H-1-imidazolylmethyl)phenyl]phenylsulfonyl}carbonylamino
SMILES: CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
InChI Key: InChIKey=PZLBCNBODYEVNF-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Angiotensin II AT2 (RAT) | BDBM50032362 (3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II | J Med Chem 38: 2938-45 (1995) BindingDB Entry DOI: 10.7270/Q2639NRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT2 (RAT) | BDBM50032362 (3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor. | J Med Chem 38: 2938-45 (1995) BindingDB Entry DOI: 10.7270/Q2639NRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (AT-1) type-1 (RAT) | BDBM50032362 (3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes | Bioorg Med Chem Lett 4: 2011-2016 (1994) Article DOI: 10.1016/S0960-894X(01)80554-0 BindingDB Entry DOI: 10.7270/Q2W37W78 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50032362 (3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of Angiotensin II receptor, type 1 | J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50032362 (3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of Angiotensin II receptor, type 2 | J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT2 (RAT) | BDBM50032362 (3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes | Bioorg Med Chem Lett 4: 2011-2016 (1994) Article DOI: 10.1016/S0960-894X(01)80554-0 BindingDB Entry DOI: 10.7270/Q2W37W78 | |||||||||||
More data for this Ligand-Target Pair |