BDBM50032954 5-(piperidin-4-yl)isoxazol-3-ol::5-Piperidin-4-yl-isoxazol-3-ol::5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL)::CHEMBL311761

SMILES: O=c1cc(o[nH]1)C1CCNCC1

InChI Key: InChIKey=YYOYGSTYWVHCJR-UHFFFAOYSA-N

Data: 1 KI  7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50032954   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human GABAA alpha-1-beta-3-gamma-2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology				J Med Chem 50: 1988-92 (2007) Article DOI: 10.1021/jm070038n BindingDB Entry DOI: 10.7270/Q2D21ZDC
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA				ACS Med Chem Lett 5: 538-43 (2014) Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4
					More data for this Ligand-Target Pair
GABA-B receptor 1/2 (Rattus norvegicus (Rat))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Inhibition of Gamma-aminobutyric acid type B receptor of rat cortex				J Med Chem 38: 3287-96 (1995) BindingDB Entry DOI: 10.7270/Q2B858S0
					More data for this Ligand-Target Pair
GABA-A receptor; alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells at < 500 uM by FMP red assay				J Med Chem 53: 3417-21 (2010) Article DOI: 10.1021/jm100106r BindingDB Entry DOI: 10.7270/Q2GF0VFM
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of plasminogen/fibrinogen interaction in pooled citrated human platelet-poor plasma assessed as inhibition of lysis of CaCl2/t-PA-induced ...				J Med Chem 56: 3273-80 (2013) Article DOI: 10.1021/jm301818g BindingDB Entry DOI: 10.7270/Q2F47QGN
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human Glu-plasminogen/fibrinogen interaction in HEPES buffer assessed as inhibition of lysis of thrombin-induced clot preincubated for ...				J Med Chem 56: 3273-80 (2013) Article DOI: 10.1021/jm301818g BindingDB Entry DOI: 10.7270/Q2F47QGN
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...				ACS Med Chem Lett 5: 538-43 (2014) Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM50032954 (5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...) Show SMILES O=c1cc(o[nH]1)C1CCNCC1 Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Affinity for GABA-B receptor by inhibiting GABA uptake into rat brain synaptosomes				J Med Chem 45: 2454-68 (2002) BindingDB Entry DOI: 10.7270/Q2D21Z91
					More data for this Ligand-Target Pair