BDBM50033066 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid::CHEMBL101308
SMILES: CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)c1ccc(cc1)C(O)=O
InChI Key: InChIKey=PBXZHEOVJMPKDY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoid receptor (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.04E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome CYP26A1 (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit... | J Med Chem 59: 2579-95 (2016) BindingDB Entry DOI: 10.7270/Q2J38VG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma (Mus musculus) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.84E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.97E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
SRI International Curated by ChEMBL | Assay Description Effective concentration against Retinoic acid receptor RXR-alpha | J Med Chem 38: 3368-83 (1995) BindingDB Entry DOI: 10.7270/Q24748WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a |
SRI International Curated by ChEMBL | Assay Description Effective concentrations against Retinoic acid receptor RXR-beta | J Med Chem 38: 3368-83 (1995) BindingDB Entry DOI: 10.7270/Q24748WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
SRI International Curated by ChEMBL | Assay Description Effective concentrations against Retinoic acid receptor RXR-gamma | J Med Chem 38: 3368-83 (1995) BindingDB Entry DOI: 10.7270/Q24748WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
SRI International Curated by ChEMBL | Assay Description Effective concentration against Retinoic acid receptor RXR-alpha | J Med Chem 38: 3368-83 (1995) BindingDB Entry DOI: 10.7270/Q24748WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma (Mus musculus) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor beta (Mus musculus) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 26B1 (Homo sapiens (Human)) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit... | J Med Chem 59: 2579-95 (2016) BindingDB Entry DOI: 10.7270/Q2J38VG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor beta (Mus musculus) | BDBM50033066 (4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthal...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 937 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells | J Med Chem 37: 2930-41 (1994) BindingDB Entry DOI: 10.7270/Q27080G3 | |||||||||||
More data for this Ligand-Target Pair |