BindingDB PrimarySearch

BDBM50033762 GALLINAMIDE A::Gallinamide A

SMILES: CC[C@H](C)[C@H](N(C)C)C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1[C@@H](C)C(OC)=CC1=O

InChI Key: InChIKey=ASRBKZHDORPEHO-KYJIWOQOSA-N

Data: 1 KI 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50033762
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Procathepsin L (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Irreversible inhibition of recombinant human cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain-2 (Plasmodium falciparum)	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Inhibition of FP2 in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysis				J Med Chem 57: 10557-63 (2014) Article DOI: 10.1021/jm501439w BindingDB Entry DOI: 10.7270/Q2TM7CQW
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
The University of Jordan Curated by ChEMBL					Assay Description Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometry				J Med Chem 62: 9026-9044 (2019) Article DOI: 10.1021/acs.jmedchem.9b00294
The University of Jordan Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Jordan Curated by ChEMBL					Assay Description Inhibition of human cathepsin L				J Med Chem 62: 9026-9044 (2019) Article DOI: 10.1021/acs.jmedchem.9b00294
The University of Jordan Curated by ChEMBL					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
The University of Jordan Curated by ChEMBL					Assay Description Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...				J Med Chem 62: 9026-9044 (2019) Article DOI: 10.1021/acs.jmedchem.9b00294
The University of Jordan Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin L2 (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Pro-cathepsin H (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrate				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin L2 (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate addition				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain-2 (Plasmodium falciparum)	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Inhibition of FP2' in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysis				J Med Chem 57: 10557-63 (2014) Article DOI: 10.1021/jm501439w BindingDB Entry DOI: 10.7270/Q2TM7CQW
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Pro-cathepsin H (Homo sapiens (Human))	BDBM50033762 (GALLINAMIDE A \| Gallinamide A) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrate				J Nat Prod 77: 92-9 (2014) Article DOI: 10.1021/np400727r BindingDB Entry DOI: 10.7270/Q2Z89GC6
University of California Curated by ChEMBL					More data for this Ligand-Target Pair