BDBM50034446 CHEMBL27065::Naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide

SMILES: Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C

InChI Key: InChIKey=ZEOXLCVRBAOHIV-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
EDNRA (RAT)	BDBM50034446 (CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...) Show SMILES Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O3S/c1-10-11(2)16-20-15(10)17-21(18,19)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,17H,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.				J Med Chem 38: 1344-54 (1995) BindingDB Entry DOI: 10.7270/Q20864BS
					More data for this Ligand-Target Pair
EDNRA (RAT)	BDBM50034446 (CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...) Show SMILES Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O3S/c1-10-11(2)16-20-15(10)17-21(18,19)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,17H,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells				J Med Chem 38: 659-68 (1995) BindingDB Entry DOI: 10.7270/Q2D799G5
					More data for this Ligand-Target Pair
EDNRB (Homo sapiens (Human))	BDBM50034446 (CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...) Show SMILES Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O3S/c1-10-11(2)16-20-15(10)17-21(18,19)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,17H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	4.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against human ETB receptor in transfected COS 7 cell membrane preparation				Bioorg Med Chem Lett 6: 2393-2398 (1996) Article DOI: 10.1016/0960-894X(96)00441-6 BindingDB Entry DOI: 10.7270/Q22V2G3R
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50034446 (CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...) Show SMILES Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O3S/c1-10-11(2)16-20-15(10)17-21(18,19)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,17H,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation				Bioorg Med Chem Lett 6: 2393-2398 (1996) Article DOI: 10.1016/0960-894X(96)00441-6 BindingDB Entry DOI: 10.7270/Q22V2G3R
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50034446 (CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...) Show SMILES Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C Show InChI InChI=1S/C15H14N2O3S/c1-10-11(2)16-20-15(10)17-21(18,19)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,17H,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cells				J Med Chem 37: 329-31 (1994) BindingDB Entry DOI: 10.7270/Q24M93KB
					More data for this Ligand-Target Pair