BDBM50041932 5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2,4-diamine::CHEMBL323155

SMILES: Nc1nc(N)c2c3CCCCc3sc2n1

InChI Key: InChIKey=OJJUOEKXPADXJS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50041932   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate Reductase (DHFR) (Escherichia coli)	BDBM50041932 (5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...) Show SMILES Nc1nc(N)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C10H12N4S/c11-8-7-5-3-1-2-4-6(5)15-9(7)14-10(12)13-8/h1-4H2,(H4,11,12,13,14)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Bacterial dihydrofolate reductase (Escherichia coli)	BDBM50041932 (5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...) Show SMILES Nc1nc(N)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C10H12N4S/c11-8-7-5-3-1-2-4-6(5)15-9(7)14-10(12)13-8/h1-4H2,(H4,11,12,13,14)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041932 (5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...) Show SMILES Nc1nc(N)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C10H12N4S/c11-8-7-5-3-1-2-4-6(5)15-9(7)14-10(12)13-8/h1-4H2,(H4,11,12,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair