BDBM50051753 1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-1-one::CHEMBL36720
SMILES: CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2
InChI Key: InChIKey=OLNNUDMXMOFMLE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50051753 (1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane | J Med Chem 39: 2554-8 (1996) Article DOI: 10.1021/jm9600508 BindingDB Entry DOI: 10.7270/Q2V69HP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50051753 (1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Affinity for the displacement of [3H]-paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes | J Med Chem 44: 1509-15 (2001) BindingDB Entry DOI: 10.7270/Q2H1318R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50051753 (1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.05 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Affinity for the displacement of [3H]-paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranes | J Med Chem 44: 1509-15 (2001) BindingDB Entry DOI: 10.7270/Q2H1318R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50051753 (1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane | J Med Chem 39: 2554-8 (1996) Article DOI: 10.1021/jm9600508 BindingDB Entry DOI: 10.7270/Q2V69HP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50051753 (1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes | J Med Chem 39: 2554-8 (1996) Article DOI: 10.1021/jm9600508 BindingDB Entry DOI: 10.7270/Q2V69HP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50051753 (1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranes | J Med Chem 44: 1509-15 (2001) BindingDB Entry DOI: 10.7270/Q2H1318R | |||||||||||
More data for this Ligand-Target Pair |