null

SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(Cc1cnc[nH]1)C(O)=O

InChI Key: InChIKey=JFYMULPOOMWHNX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50054215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Folylpolyglutamate synthase, mitochondrial (Homo sapiens (Human))	BDBM50054215 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(Cc1cnc[nH]1)C(O)=O Show InChI InChI=1S/C21H22N10O3/c1-31(9-13-8-25-18-16(27-13)17(22)29-21(23)30-18)14-4-2-11(3-5-14)19(32)28-15(20(33)34)6-12-7-24-10-26-12/h2-5,7-8,10,15H,6,9H2,1H3,(H,24,26)(H,28,32)(H,33,34)(H4,22,23,25,29,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against Folyl-polyglutamate synthase from CCRF-CEM human leukemia cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM50054215 (2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...) Show SMILES CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(Cc1cnc[nH]1)C(O)=O Show InChI InChI=1S/C21H22N10O3/c1-31(9-13-8-25-18-16(27-13)17(22)29-21(23)30-18)14-4-2-11(3-5-14)19(32)28-15(20(33)34)6-12-7-24-10-26-12/h2-5,7-8,10,15H,6,9H2,1H3,(H,24,26)(H,28,32)(H,33,34)(H4,22,23,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
State University of New York Curated by ChEMBL					Assay Description compound was evaluated for the inhibitory activity against Dihydrofolate reductase in permeabilised L1210 cells.				J Med Chem 39: 4340-4 (1996) Article DOI: 10.1021/jm960250j BindingDB Entry DOI: 10.7270/Q2JH3K8H
					More data for this Ligand-Target Pair