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BDBM50055810 1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piperazine::1-phenyl-4-((2-phenyl-1H-imidazol-4-yl)methyl)piperazine::CHEMBL103871

SMILES: C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1

InChI Key: InChIKey=PORLBUSMWVWYQB-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50055810   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50055810
PNG
(1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-17(8-4-1)20-21-15-18(22-20)16-23-11-13-24(14-12-23)19-9-5-2-6-10-19/h1-10,15H,11-14,16H2,(H,21,22)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.60n/an/an/an/an/an/an/an/a



Universidade Federal do Rio Grande do Sul

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D4 receptor


Bioorg Med Chem 18: 1925-35 (2010)


Article DOI: 10.1016/j.bmc.2010.01.040
BindingDB Entry DOI: 10.7270/Q2S75H99
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50055810
PNG
(1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-17(8-4-1)20-21-15-18(22-20)16-23-11-13-24(14-12-23)19-9-5-2-6-10-19/h1-10,15H,11-14,16H2,(H,21,22)
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PC cid
PC sid
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PubMed
5.20n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Binding affinity on human Dopamine receptor D4 expressed in CHO cells using radioligand [3H]-YM 09151


J Med Chem 40: 1-3 (1997)


Article DOI: 10.1021/jm960637m
BindingDB Entry DOI: 10.7270/Q21C1W0V
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50055810
PNG
(1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-17(8-4-1)20-21-15-18(22-20)16-23-11-13-24(14-12-23)19-9-5-2-6-10-19/h1-10,15H,11-14,16H2,(H,21,22)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
193n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Binding affinity on human Dopamine receptor D3 expressed in CHO cells using radioligand [3H]-YM 09151


J Med Chem 40: 1-3 (1997)


Article DOI: 10.1021/jm960637m
BindingDB Entry DOI: 10.7270/Q21C1W0V
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50055810
PNG
(1-Phenyl-4-(2-phenyl-3H-imidazol-4-ylmethyl)-piper...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-17(8-4-1)20-21-15-18(22-20)16-23-11-13-24(14-12-23)19-9-5-2-6-10-19/h1-10,15H,11-14,16H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
254n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Binding affinity on human Dopamine receptor D2 expressed in CHO cells using radioligand [3H]-YM 09151


J Med Chem 40: 1-3 (1997)


Article DOI: 10.1021/jm960637m
BindingDB Entry DOI: 10.7270/Q21C1W0V
More data for this
Ligand-Target Pair