BDBM50063697 2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4-one::CHEMBL274816

SMILES: Clc1ccc(Cl)c(Nc2nc3ccccc3c(=O)o2)c1

InChI Key: InChIKey=ZABGGFDOFFLQFO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50063697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement C1r subcomponent (Homo sapiens (Human))	BDBM50063697 (2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...) Show SMILES Clc1ccc(Cl)c(Nc2nc3ccccc3c(=O)o2)c1 Show InChI InChI=1S/C14H8Cl2N2O2/c15-8-5-6-10(16)12(7-8)18-14-17-11-4-2-1-3-9(11)13(19)20-14/h1-7H,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description 50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrate				J Med Chem 41: 1060-7 (1998) Article DOI: 10.1021/jm970394d BindingDB Entry DOI: 10.7270/Q2PZ57ZT
					More data for this Ligand-Target Pair
Trypsin (Bos taurus (bovine))	BDBM50063697 (2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...) Show SMILES Clc1ccc(Cl)c(Nc2nc3ccccc3c(=O)o2)c1 Show InChI InChI=1S/C14H8Cl2N2O2/c15-8-5-6-10(16)12(7-8)18-14-17-11-4-2-1-3-9(11)13(19)20-14/h1-7H,(H,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Concentration of compound required to inhibit 50% trypsin derived from bovine pancreas				J Med Chem 41: 1060-7 (1998) Article DOI: 10.1021/jm970394d BindingDB Entry DOI: 10.7270/Q2PZ57ZT
					More data for this Ligand-Target Pair
Complement C1r subcomponent (Homo sapiens (Human))	BDBM50063697 (2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...) Show SMILES Clc1ccc(Cl)c(Nc2nc3ccccc3c(=O)o2)c1 Show InChI InChI=1S/C14H8Cl2N2O2/c15-8-5-6-10(16)12(7-8)18-14-17-11-4-2-1-3-9(11)13(19)20-14/h1-7H,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrate				J Med Chem 41: 1060-7 (1998) Article DOI: 10.1021/jm970394d BindingDB Entry DOI: 10.7270/Q2PZ57ZT
					More data for this Ligand-Target Pair