BindingDB PrimarySearch

BDBM50072297 (S)-5-Acetimidoylamino-2-amino-pent::(S)-5-Acetimidoylamino-2-amino-pentanoic acid::5-Acetimidoylamino-2-(S)-amino-pentanoic acid::CHEMBL11471::L-NIO, 12::N5-(1-iminoethyl)-L-ornithine::N5-IMINOETHYL-L-ORNITHINE

SMILES: CC(N)=NCCC[C@H](N)C(O)=O

InChI Key: InChIKey=UYZFAUAYFLEHRC-LURJTMIESA-N

Data: 7 KI 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50072297
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory constant for the inhibition of human Neuronal nitric oxide synthase				Bioorg Med Chem Lett 7: 1763-1768 (1997) Article DOI: 10.1016/S0960-894X(97)00309-0 BindingDB Entry DOI: 10.7270/Q2TQ61J5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory constant for the inhibition of human Inducible nitric oxide synthase				Bioorg Med Chem Lett 7: 1763-1768 (1997) Article DOI: 10.1016/S0960-894X(97)00309-0 BindingDB Entry DOI: 10.7270/Q2TQ61J5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article	810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory constant for the inhibition of human Endothelial nitric oxide synthase				Bioorg Med Chem Lett 7: 1763-1768 (1997) Article DOI: 10.1016/S0960-894X(97)00309-0 BindingDB Entry DOI: 10.7270/Q2TQ61J5
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric Oxide Synthase, inducible (Mus musculus (mouse))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University at Buffalo Curated by ChEMBL					Assay Description Compound was tested for competitive antagonist of Nitric oxide synthase				Bioorg Med Chem Lett 10: 1077-80 (2000) BindingDB Entry DOI: 10.7270/Q2959GSN
University at Buffalo Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica Curated by ChEMBL					Assay Description Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrulline				Bioorg Med Chem 16: 6193-206 (2008) Article DOI: 10.1016/j.bmc.2008.04.036 BindingDB Entry DOI: 10.7270/Q2611040
Instituto de Química Médica Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric-oxide synthase, brain (Rattus norvegicus (rat))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas					Assay Description Inhibition assay using DDAH-1 and nNOS.				Biochemistry 48: 8624-35 (2009) Article DOI: 10.1021/bi9007098 BindingDB Entry DOI: 10.7270/Q29C6W1P
The University of Texas					More data for this Ligand-Target Pair
Dimethylarginine dimethylaminohydrolase 1 (DDAH) (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	9.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas					Assay Description Inhibition assay using DDAH-1 and nNOS.				Biochemistry 48: 8624-35 (2009) Article DOI: 10.1021/bi9007098 BindingDB Entry DOI: 10.7270/Q29C6W1P
The University of Texas					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibitory concentration against human neuronal nitric oxide synthase expressed in Sf-9 cells				Bioorg Med Chem Lett 15: 2881-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.078 BindingDB Entry DOI: 10.7270/Q2PK0FP1
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Rattus norvegicus)	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
G. D. Searle Research and Development Curated by ChEMBL					Assay Description Tested for inhibition of rat brain inducible nitric oxide synthase				J Med Chem 37: 3886-8 (1994) BindingDB Entry DOI: 10.7270/Q29P328V
G. D. Searle Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibitory concentration against human endothelial nitric oxide synthase expressed in Sf-9 cells				Bioorg Med Chem Lett 15: 2881-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.078 BindingDB Entry DOI: 10.7270/Q2PK0FP1
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric Oxide Synthase, inducible (Mus musculus (mouse))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université de Haute-Alsace Curated by ChEMBL					Assay Description Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.				Bioorg Med Chem Lett 8: 2961-6 (1999) Article DOI: 10.1016/S0960-894X(98)00532-0 BindingDB Entry DOI: 10.7270/Q2DZ07G5
Université de Haute-Alsace Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric Oxide Synthase, inducible (Mus musculus (mouse))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
G. D. Searle Research and Development Curated by ChEMBL					Assay Description Tested for inhibition of mouse inducible nitric oxide synthase				J Med Chem 37: 3886-8 (1994) BindingDB Entry DOI: 10.7270/Q29P328V
G. D. Searle Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50072297 ((S)-5-Acetimidoylamino-2-amino-pent \| (S)-5-Acetim...) Show SMILES CC(N)=NCCC[C@H](N)C(O)=O \|r,w:3.3\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibitory concentration against human inducible nitric oxide synthase expressed in Sf-9 cells				Bioorg Med Chem Lett 15: 2881-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.078 BindingDB Entry DOI: 10.7270/Q2PK0FP1
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair