BDBM50081588 1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-propane-1,2-diol::CHEMBL318427
SMILES: CC(O)C(O)C1CNc2nc(N)nc(N)c2N1
InChI Key: InChIKey=NDSDGUULXHNXGA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nitric-oxide synthase, endothelial (Sus scrofa) | BDBM50081588 (1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Julius-Maximilians University Würzburg Curated by ChEMBL | Assay Description Inhibitory activity against Nitric oxide synthase (derived from porcine brain cerebellum) | J Med Chem 42: 4108-21 (1999) BindingDB Entry DOI: 10.7270/Q27H1HSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50081588 (1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Aventis Pharma Curated by ChEMBL | Assay Description Inhibitory activity against human neuronal nitric oxide synthase (NOS-I) | J Med Chem 45: 2923-41 (2002) BindingDB Entry DOI: 10.7270/Q2571BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, brain (Homo sapiens (Human)) | BDBM50081588 (1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Aventis Curated by ChEMBL | Assay Description Inhibitory activity against human Nitric oxide synthase-I with 2 uM H4Bip for 30 min | J Med Chem 48: 4783-92 (2005) Article DOI: 10.1021/jm050007x BindingDB Entry DOI: 10.7270/Q28W3CTH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, inducible (Homo sapiens (Human)) | BDBM50081588 (1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Aventis Curated by ChEMBL | Assay Description Inhibitory activity against human Nitric oxide synthase-II with 2 uM H4Bip for 30 min | J Med Chem 48: 4783-92 (2005) Article DOI: 10.1021/jm050007x BindingDB Entry DOI: 10.7270/Q28W3CTH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (Homo sapiens (Human)) | BDBM50081588 (1-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 5.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Aventis Curated by ChEMBL | Assay Description Inhibitory activity against human Nitric oxide synthase-III with 2 uM H4Bip for 30 min | J Med Chem 48: 4783-92 (2005) Article DOI: 10.1021/jm050007x BindingDB Entry DOI: 10.7270/Q28W3CTH | |||||||||||
More data for this Ligand-Target Pair |