BindingDB PrimarySearch

BDBM50087016 8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL281274::Ro65-6570

SMILES: O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23

InChI Key: InChIKey=BBOAHBVXCYBKLC-UHFFFAOYSA-N

Data: 8 KI 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50087016
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding affinity against transfected HEK293 cells expressing human Opioid receptor like 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leicester Royal Infirmary Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 363: 28-33 (2001) Article DOI: 10.1007/s002100000327 BindingDB Entry DOI: 10.7270/Q2TH8K8W
Leicester Royal Infirmary Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leicester Royal Infirmary Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 363: 28-33 (2001) Article DOI: 10.1007/s002100000327 BindingDB Entry DOI: 10.7270/Q2TH8K8W
Leicester Royal Infirmary Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leicester Royal Infirmary Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 363: 28-33 (2001) Article DOI: 10.1007/s002100000327 BindingDB Entry DOI: 10.7270/Q2TH8K8W
Leicester Royal Infirmary Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	302	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leicester Royal Infirmary Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 363: 28-33 (2001) Article DOI: 10.1007/s002100000327 BindingDB Entry DOI: 10.7270/Q2TH8K8W
Leicester Royal Infirmary Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Effective concentration of the required to stimulate binding of GTPgammaS to mu1 receptor was determined using scintillation proximity assay				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50087016 (8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assay				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair