BDBM50092615 CHEMBL3586361

SMILES: C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12

InChI Key:

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50092615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50092615 (CHEMBL3586361) Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay				J Med Chem 58: 5256-73 (2015) Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (EP1) (Homo sapiens (Human))	BDBM50092615 (CHEMBL3586361) Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12 |r| Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from human EP1 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay				J Med Chem 58: 5256-73 (2015) Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50092615 (CHEMBL3586361) Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production				J Med Chem 58: 5256-73 (2015) Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50092615 (CHEMBL3586361) Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from human EP3 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay				J Med Chem 58: 5256-73 (2015) Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50092615 (CHEMBL3586361) Show SMILES C[C@@H]1COc2c(Cl)cc(cc2CN1Cc1cc[nH]c(=O)c1)-c1csc2ccccc12 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay				J Med Chem 58: 5256-73 (2015) Article DOI: 10.1021/acs.jmedchem.5b00567 BindingDB Entry DOI: 10.7270/Q2416ZSC
					More data for this Ligand-Target Pair