BindingDB PrimarySearch

null

SMILES: OP(O)(=O)C(=O)NCCc1ccccc1

InChI Key: InChIKey=GHFCXEYUGIXTHN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50112446
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>5.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharma Curated by ChEMBL					Assay Description The compound was evaluated for its binding affinity towards phosphotyrosine binding pocket of Src protein tryrosine kinase SH2 domain				Bioorg Med Chem Lett 12: 1295-8 (2002) BindingDB Entry DOI: 10.7270/Q2959GW0
Aventis Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-3 was determined				J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-8 was determined				J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-9 was determined				J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-2 was determined				J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of MMP2				J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human Carbonic anhydrase 12-mediated CO2 hydration by stopped-flow method				J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human Carbonic anhydrase 9-mediated CO2 hydration by stopped-flow method				J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human Carbonic anhydrase 2-mediated CO2 hydration by stopped-flow method				J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description Inhibition of human Carbonic anhydrase 1-mediated CO2 hydration by stopped-flow method				J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50112446 (CHEMBL24447 \| [(2-phenylethyl)amino]carbonylphosph...) Show SMILES OP(O)(=O)C(=O)NCCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Hebrew University of Jerusalem Curated by ChEMBL					Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-1 was determined				J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C
The Hebrew University of Jerusalem Curated by ChEMBL					More data for this Ligand-Target Pair