BDBM50116409 2-(2-Chloro-6-methyl-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione::CHEMBL114816

SMILES: Cc1cccc(Cl)c1Nc1nc2ccc3c(C(=O)NC(=O)C3(C)C)c2[nH]1

InChI Key: InChIKey=WDMYTYYNCYQJQX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50116409   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50116409 (2-(2-Chloro-6-methyl-phenylamino)-6,6-dimethyl-1,6...) Show SMILES Cc1cccc(Cl)c1Nc1nc2ccc3c(C(=O)NC(=O)C3(C)C)c2[nH]1 Show InChI InChI=1S/C19H17ClN4O2/c1-9-5-4-6-11(20)14(9)22-18-21-12-8-7-10-13(15(12)23-18)16(25)24-17(26)19(10,2)3/h4-8H,1-3H3,(H2,21,22,23)(H,24,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human p56 Lck tyrosine kinase				J Med Chem 45: 3394-405 (2002) BindingDB Entry DOI: 10.7270/Q2CJ8CTW
					More data for this Ligand-Target Pair