BDBM50124205 2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile::CHEMBL443038

SMILES: O=c1[nH]cc(C#N)c(=O)[nH]1

InChI Key: InChIKey=HAUXRJCZDHHADG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50124205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124205 (2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonit...) Show SMILES O=c1[nH]cc(C#N)c(=O)[nH]1 Show InChI InChI=1S/C5H3N3O2/c6-1-3-2-7-5(10)8-4(3)9/h2H,(H2,7,8,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair