BDBM50126760 2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(3-morpholin-4-yl-3-oxo-propyl)-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL26147

SMILES: Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CCC(=O)N1CCOCC1

InChI Key: InChIKey=ISNFTACXVBSUFU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50126760 (2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(3-mor...) Show SMILES Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CCC(=O)N1CCOCC1 Show InChI InChI=1S/C25H25Cl2N5O3/c1-14-15(7-9-20(33)32-10-12-35-13-11-32)16-6-8-19-23(21(16)24(34)28-14)31(2)25(29-19)30-22-17(26)4-3-5-18(22)27/h3-6,8H,7,9-13H2,1-2H3,(H,28,34)(H,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of p56 Lck tyrosine kinase				J Med Chem 46: 1337-49 (2003) Article DOI: 10.1021/jm020446l BindingDB Entry DOI: 10.7270/Q2DN44FW
					More data for this Ligand-Target Pair