BDBM50136824 (4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl)methyl)-25-amino-13-(4-aminobutyl)-7,19,22-tribenzyl-10-((R)-1-hydroxyethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosane-4-carboxylic acid::(S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-10-((R)-1-hydroxy-ethyl)-16-(1H-indol-3-ylmethyl)-6,12,15,18-tetra(S)-oxo-9,21-di(R)-oxo-24-oxo-1,2-dithia-5,8,11,14,17,20,23-heptaaza-cyclohexacosane-4-carboxylic acid::CHEMBL266477::H-c(Cys3-Phe6-Phe7-DTrp8-Lys9-Thr10-Phe11-Cys14)-OH::ODT-8
SMILES: C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
InChI Key: InChIKey=PJRZZHKHLDKTKL-AYVMSDBXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Binding affinity towards human Somatostatin receptor type 1 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand | J Med Chem 46: 5606-18 (2003) Article DOI: 10.1021/jm030246p BindingDB Entry DOI: 10.7270/Q2GT5MMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
The Clayton Foundation Laboratories for Peptide Biology Curated by ChEMBL | Assay Description Displacement of [125I]LTT-SRIF-28 from human sst2 receptor by autoradiography | J Med Chem 52: 2733-46 (2009) Article DOI: 10.1021/jm801314f BindingDB Entry DOI: 10.7270/Q2CV4JPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Binding affinity towards human Somatostatin receptor type 3 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand | J Med Chem 46: 5606-18 (2003) Article DOI: 10.1021/jm030246p BindingDB Entry DOI: 10.7270/Q2GT5MMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Binding affinity towards human Somatostatin receptor type 2 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand | J Med Chem 46: 5606-18 (2003) Article DOI: 10.1021/jm030246p BindingDB Entry DOI: 10.7270/Q2GT5MMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Binding affinity towards human Somatostatin receptor type 4 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand | J Med Chem 46: 5606-18 (2003) Article DOI: 10.1021/jm030246p BindingDB Entry DOI: 10.7270/Q2GT5MMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of 125I-[LTT]-SRIF-28 from human sst3 receptor in CCL39 cells after 2 hrs by autoradiography | J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of 125I-[LTT]-SRIF-28 from human sst5 receptor in HEK293 cells after 2 hrs by autoradiography | J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.33 | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay | J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography | J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of 125I-[LTT]-SRIF-28 from human sst2 receptor in CCL39 cells after 2 hrs by autoradiography | J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of 125I-[LTT]-SRIF-28 from human sst4 receptor in CCL39 cells after 2 hrs by autoradiography | J Med Chem 54: 5981-7 (2011) Article DOI: 10.1021/jm200307v BindingDB Entry DOI: 10.7270/Q2BV7H1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 2 | J Med Chem 48: 515-22 (2005) Article DOI: 10.1021/jm049519m BindingDB Entry DOI: 10.7270/Q2QV3N9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 3 | J Med Chem 48: 515-22 (2005) Article DOI: 10.1021/jm049519m BindingDB Entry DOI: 10.7270/Q2QV3N9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 5 | J Med Chem 48: 515-22 (2005) Article DOI: 10.1021/jm049519m BindingDB Entry DOI: 10.7270/Q2QV3N9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 1 | J Med Chem 48: 515-22 (2005) Article DOI: 10.1021/jm049519m BindingDB Entry DOI: 10.7270/Q2QV3N9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 4 | J Med Chem 48: 515-22 (2005) Article DOI: 10.1021/jm049519m BindingDB Entry DOI: 10.7270/Q2QV3N9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human cloned sst1 receptor | J Med Chem 51: 2668-75 (2008) Article DOI: 10.1021/jm701444y BindingDB Entry DOI: 10.7270/Q2CF9R1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst2 receptor expressed in CCL39 cells | J Med Chem 51: 2668-75 (2008) Article DOI: 10.1021/jm701444y BindingDB Entry DOI: 10.7270/Q2CF9R1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst3 receptor expressed in CCL39 cells | J Med Chem 51: 2668-75 (2008) Article DOI: 10.1021/jm701444y BindingDB Entry DOI: 10.7270/Q2CF9R1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst4 receptor expressed in CCL39 cells | J Med Chem 51: 2668-75 (2008) Article DOI: 10.1021/jm701444y BindingDB Entry DOI: 10.7270/Q2CF9R1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF-28 from human cloned sst5 receptor expressed in CHOK1 cells | J Med Chem 51: 2668-75 (2008) Article DOI: 10.1021/jm701444y BindingDB Entry DOI: 10.7270/Q2CF9R1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
The Clayton Foundation Laboratories for Peptide Biology Curated by ChEMBL | Assay Description Displacement of [125I]LTT-SRIF-28 from human sst3 receptor by autoradiography | J Med Chem 52: 2733-46 (2009) Article DOI: 10.1021/jm801314f BindingDB Entry DOI: 10.7270/Q2CV4JPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
The Clayton Foundation Laboratories for Peptide Biology Curated by ChEMBL | Assay Description Displacement of [125I]LTT-SRIF-28 from human sst4 receptor by autoradiography | J Med Chem 52: 2733-46 (2009) Article DOI: 10.1021/jm801314f BindingDB Entry DOI: 10.7270/Q2CV4JPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
The Clayton Foundation Laboratories for Peptide Biology Curated by ChEMBL | Assay Description Displacement of [125I]LTT-SRIF-28 from human sst5 receptor by autoradiography | J Med Chem 52: 2733-46 (2009) Article DOI: 10.1021/jm801314f BindingDB Entry DOI: 10.7270/Q2CV4JPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
The Clayton Foundation Laboratories for Peptide Biology Curated by ChEMBL | Assay Description Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography | J Med Chem 52: 2733-46 (2009) Article DOI: 10.1021/jm801314f BindingDB Entry DOI: 10.7270/Q2CV4JPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50136824 ((4R,7S,10S,13S,16R,19S,22S,25R)-16-((1H-indol-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Salk Institute Curated by ChEMBL | Assay Description Binding affinity towards human Somatostatin receptor type 5 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand | J Med Chem 46: 5606-18 (2003) Article DOI: 10.1021/jm030246p BindingDB Entry DOI: 10.7270/Q2GT5MMN | |||||||||||
More data for this Ligand-Target Pair |