BDBM50137124 4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid::4-chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid::CHEMBL346524

SMILES: OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1

InChI Key: InChIKey=ODWUYZAAMNLBKT-UHFFFAOYSA-N

Data: 15 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50137124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 4 of HEK293 cells in FLIPR assay				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding inhibition of compound against Ionotropic glutamate receptor ionotropic kainate 1 (GluR5) using [3H]-ATPA as radioligand				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 2 of HEK293 cells in FLIPR assay				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor ionotropic kainate 2 (GluR-6) of HEK293 cells in FLIPR assay				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 3 of HEK293 cells in FLIPR assay				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
GRIA1 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 1 of HEK293 cells in FLIPR assay				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at rat homomeric recombinant GluR3 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4 (Rattus norvegicus)	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at rat homomeric recombinant GluR4 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at human homomeric GluR6 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLIPR assay				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at human homomeric GluR5 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLIPR assay				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Displacement of [3HATPA from human recombinant GluR5				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2 (Rattus norvegicus)	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at rat homomeric recombinant GluR2 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Antagonist activity at rat homomeric recombinant GluR1 expressed in HEK293 cells assessed as inhibition of intracellular calcium concentration by FLI...				J Med Chem 47: 6948-57 (2004) Article DOI: 10.1021/jm030638w BindingDB Entry DOI: 10.7270/Q2SQ8ZVT
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50137124 (4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.				J Med Chem 46: 5834-43 (2003) Article DOI: 10.1021/jm030428j BindingDB Entry DOI: 10.7270/Q2KK9B60
					More data for this Ligand-Target Pair