BDBM50140714 CHEMBL27142::methyl 5-(3,4-dichlorophenyl)-4,6-dioxo-3-phenyl-(3R,3aS,6aR)-perhydropyrrolo[3,4-c]pyrrole-1-carboxylate

SMILES: COC(=O)C1NC(c2c(O)n(c(O)c12)-c1ccc(Cl)c(Cl)c1)c1ccccc1

InChI Key: InChIKey=GEMYJIADYZLHLI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50140714   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phenylalanyl-tRNA synthetase alpha chain (Streptococcus pyogenes serotype M18)	BDBM50140714 (CHEMBL27142 | methyl 5-(3,4-dichlorophenyl)-4,6-di...) Show SMILES COC(=O)C1NC(c2c(O)n(c(O)c12)-c1ccc(Cl)c(Cl)c1)c1ccccc1 Show InChI InChI=1S/C20H16Cl2N2O4/c1-28-20(27)17-15-14(16(23-17)10-5-3-2-4-6-10)18(25)24(19(15)26)11-7-8-12(21)13(22)9-11/h2-9,16-17,23,25-26H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus				Bioorg Med Chem Lett 14: 1339-42 (2004) Article DOI: 10.1016/j.bmcl.2003.11.081 BindingDB Entry DOI: 10.7270/Q2PR7VDS
					More data for this Ligand-Target Pair
Phenylalanyl-tRNA synthetase alpha chain (Streptococcus pyogenes serotype M18)	BDBM50140714 (CHEMBL27142 | methyl 5-(3,4-dichlorophenyl)-4,6-di...) Show SMILES COC(=O)C1NC(c2c(O)n(c(O)c12)-c1ccc(Cl)c(Cl)c1)c1ccccc1 Show InChI InChI=1S/C20H16Cl2N2O4/c1-28-20(27)17-15-14(16(23-17)10-5-3-2-4-6-10)18(25)24(19(15)26)11-7-8-12(21)13(22)9-11/h2-9,16-17,23,25-26H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis				Bioorg Med Chem Lett 14: 1339-42 (2004) Article DOI: 10.1016/j.bmcl.2003.11.081 BindingDB Entry DOI: 10.7270/Q2PR7VDS
					More data for this Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial (Homo sapiens (Human))	BDBM50140714 (CHEMBL27142 | methyl 5-(3,4-dichlorophenyl)-4,6-di...) Show SMILES COC(=O)C1NC(c2c(O)n(c(O)c12)-c1ccc(Cl)c(Cl)c1)c1ccccc1 Show InChI InChI=1S/C20H16Cl2N2O4/c1-28-20(27)17-15-14(16(23-17)10-5-3-2-4-6-10)18(25)24(19(15)26)11-7-8-12(21)13(22)9-11/h2-9,16-17,23,25-26H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cubist Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human phenylalanyl-tRNA synthetase was determined				Bioorg Med Chem Lett 14: 1339-42 (2004) Article DOI: 10.1016/j.bmcl.2003.11.081 BindingDB Entry DOI: 10.7270/Q2PR7VDS
					More data for this Ligand-Target Pair