BindingDB PrimarySearch

BDBM50141809 2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-methoxy-quinolin-7-yloxy}-ethylamino)-ethanol::CHEMBL352308

SMILES: COc1cc2c(Oc3ccc(Nc4ccc(cc4)C(C)(C)C)cc3)ccnc2cc1OCCNCCO

InChI Key: InChIKey=VQCDZFWRGXFUMS-UHFFFAOYSA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50141809
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of PDGF-receptor autophosphorylation in intact cells				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of IGF-receptor 1 autophosphorylation in intact cells				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of EGF-receptor autophosphorylation in intact cells				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Met autophosphorylation of in intact cells				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell line				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of VEGFR2				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Kit autophosphorylation in intact cells				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of c-Kit				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of FGFR2				J Med Chem 55: 10797-822 (2012) Article DOI: 10.1021/jm301085w BindingDB Entry DOI: 10.7270/Q2BP03XZ
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50141809 (2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Kirin Brewery Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of vascular endothelial growth factor receptor 2 autophosphorylation in intact cells				Bioorg Med Chem Lett 14: 875-9 (2004) Article DOI: 10.1016/j.bmcl.2003.12.019 BindingDB Entry DOI: 10.7270/Q2TB16BV
Kirin Brewery Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair