BindingDB logo
myBDB logout

BDBM50147983 2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-4-methyl-4H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide::CHEMBL105251

SMILES: Cc1c([nH]nc1-c1cccc(Cl)c1Cl)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1

InChI Key: InChIKey=REXLZFATHYEDFP-XMMPIXPASA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50147983   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-2 receptor alpha chain


(Mus musculus)		BDBM50147983
PNG
(2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-4-me...)
Show SMILES Cc1c([nH]nc1-c1cccc(Cl)c1Cl)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1 |wD:26.29,(-4.64,-2.92,;-4.33,-1.4,;-2.93,-.75,;-3.12,.77,;-4.64,1.07,;-5.38,-.28,;-6.91,-.45,;-7.83,.79,;-9.37,.6,;-9.98,-.82,;-9.05,-2.05,;-9.68,-3.46,;-7.53,-1.87,;-6.62,-3.11,;-1.59,-1.5,;-1.58,-3.06,;-.25,-3.8,;1.08,-3.02,;1.07,-1.48,;-.27,-.72,;2.43,-3.78,;2.43,-5.32,;3.74,-2.99,;5.09,-3.76,;6.42,-2.97,;6.4,-1.43,;7.75,-3.73,;9.08,-2.95,;10.43,-3.69,;10.44,-5.23,;11.76,-2.92,;7.78,-5.27,;6.45,-6.04,;6.45,-7.58,;7.79,-8.34,;9.12,-7.56,;9.11,-6.02,)|
Show InChI InChI=1S/C26H35Cl2N7O2/c1-15-22(33-34-23(15)18-8-5-9-19(27)21(18)28)17-10-12-35(13-11-17)20(36)14-31-25(37)24(32-26(29)30)16-6-3-2-4-7-16/h5,8-9,16-17,24H,2-4,6-7,10-14H2,1H3,(H,31,37)(H,33,34)(H4,29,30,32)/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.00E+5n/an/an/an/an/an/a



Sunesis Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay

J Med Chem 47: 3111-30 (2004)


Article DOI: 10.1021/jm049967u
BindingDB Entry DOI: 10.7270/Q2TQ6280
More data for this
Ligand-Target Pair