BDBM50148001 2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(2,3-dichloro-4-methoxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-amide::CHEMBL421412

SMILES: [#6]-[#8]-c1ccc(-c2cc(-[#6]-3-[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#6])-[#6])\[#7]=[#6](/[#7])-[#7])n(-[#6])n2)c(Cl)c1Cl

InChI Key: InChIKey=LOHFCUXSVNYHLN-GOSISDBHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50148001   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-2 receptor alpha chain (Mus musculus)	BDBM50148001 (2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(2,3-...) Show SMILES [#6]-[#8]-c1ccc(-c2cc(-[#6]-3-[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#6])-[#6])\[#7]=[#6](/[#7])-[#7])n(-[#6])n2)c(Cl)c1Cl Show InChI InChI=1S/C25H35Cl2N7O3/c1-14(2)11-18(31-25(28)29)24(36)30-13-21(35)34-9-7-15(8-10-34)19-12-17(32-33(19)3)16-5-6-20(37-4)23(27)22(16)26/h5-6,12,14-15,18H,7-11,13H2,1-4H3,(H,30,36)(H4,28,29,31)/t18-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay				J Med Chem 47: 3111-30 (2004) Article DOI: 10.1021/jm049967u BindingDB Entry DOI: 10.7270/Q2TQ6280
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