BDBM50154444 2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid::CHEMBL188307

SMILES: OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1

InChI Key: InChIKey=IHENRRNKCCTTGR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50154444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50154444 (2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Hepatitis C virus NS5B RNA-dependent RNA polymerase (Hepatitis C virus)	BDBM50154444 (2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)	UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mg2+ is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
DNA polymerase I (Escherichia coli (strain K12))	BDBM50154444 (2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit Klenow DNA-dependent DNA polymerase				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50154444 (2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HIV-integrase is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50154444 (2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-...) Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C18H14N2O5/c21-15-14(18(23)24)19-16(20-17(15)22)12-7-4-8-13(9-12)25-10-11-5-2-1-3-6-11/h1-9,21H,10H2,(H,23,24)(H,19,20,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Italy. Vinc Curated by ChEMBL					Assay Description Inhibitory concentration required to inhibit HIV-RT is determined				J Med Chem 47: 5336-9 (2004) Article DOI: 10.1021/jm0494669 BindingDB Entry DOI: 10.7270/Q2G1609M
					More data for this Ligand-Target Pair