BDBM50155241 CHEMBL3774885

SMILES: Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCOCC2)cc1

InChI Key: InChIKey=FGWWXXXOMYTMPD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50155241 (CHEMBL3774885) Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O2/c1-27-15-19(14-24-27)17-4-2-16(3-5-17)12-22-20-13-18(6-7-21(20)25-26-22)23(29)28-8-10-30-11-9-28/h2-7,13-15H,8-12H2,1H3,(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50155241 (CHEMBL3774885) Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O2/c1-27-15-19(14-24-27)17-4-2-16(3-5-17)12-22-20-13-18(6-7-21(20)25-26-22)23(29)28-8-10-30-11-9-28/h2-7,13-15H,8-12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
					More data for this Ligand-Target Pair