BDBM50157562 1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one::3,3',4,4'-tetrahydroxychalcone::CHEMBL225618::US9085549, 94

SMILES: Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O

InChI Key: InChIKey=DOWSJIIZLUFMFM-DAFODLJHSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50157562   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-synuclein (Homo sapiens (Human))	BDBM50157562 (1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O Show InChI InChI=1S/C15H12O5/c16-11(10-3-6-13(18)15(20)8-10)4-1-9-2-5-12(17)14(19)7-9/h1-8,17-20H/b4-1+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
PROTEOTECH INC US Patent					Assay Description The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...				US Patent US9085549 (2015) BindingDB Entry DOI: 10.7270/Q2WD3Z9K
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50157562 (1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O Show InChI InChI=1S/C15H12O5/c16-11(10-3-6-13(18)15(20)8-10)4-1-9-2-5-12(17)14(19)7-9/h1-8,17-20H/b4-1+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
BU-Nerviano Medical Sciences Curated by ChEMBL					Assay Description Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay				J Med Chem 47: 6466-75 (2004) Article DOI: 10.1021/jm040810b BindingDB Entry DOI: 10.7270/Q2P55N1R
					More data for this Ligand-Target Pair
Xanthine dehydrogenase (Bos taurus (Bovine))	BDBM50157562 (1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O Show InChI InChI=1S/C15H12O5/c16-11(10-3-6-13(18)15(20)8-10)4-1-9-2-5-12(17)14(19)7-9/h1-8,17-20H/b4-1+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Kentucky University Curated by ChEMBL					Assay Description Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysis				Bioorg Med Chem 24: 578-87 (2016) BindingDB Entry DOI: 10.7270/Q23F4RJT
					More data for this Ligand-Target Pair
Tau (Homo sapiens (Human))	BDBM50157562 (1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...) Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O Show InChI InChI=1S/C15H12O5/c16-11(10-3-6-13(18)15(20)8-10)4-1-9-2-5-12(17)14(19)7-9/h1-8,17-20H/b4-1+	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
PROTEOTECH INC US Patent					Assay Description The Thio S fluorometry assay as a primary screening method to identify tau protein aggregation inhibitors from our small molecule library. Aggregated...				US Patent US9085549 (2015) BindingDB Entry DOI: 10.7270/Q2WD3Z9K
					More data for this Ligand-Target Pair