BDBM50172373 CHEMBL197473::Cyclopropanecarboxylic acid (8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-phenyl-amide
SMILES: COc1c(CN(C(=O)C2CC2)c2ccccc2)ccc2C=CC(C)(C)Oc12
InChI Key: InChIKey=AYBGMHSHUIBQAY-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bile acid receptor (Homo sapiens (Human)) | BDBM50172373 (CHEMBL197473 | Cyclopropanecarboxylic acid (8-meth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Effective concentration towards farnesoid X receptor (FXR); Range is 5-10 uM | J Med Chem 48: 5613-38 (2005) Article DOI: 10.1021/jm050524f BindingDB Entry DOI: 10.7270/Q2V988V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bile acid receptor (Homo sapiens (Human)) | BDBM50172373 (CHEMBL197473 | Cyclopropanecarboxylic acid (8-meth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Effective concentration against farnesoid X receptor (FXR); range is 5-10 uM | J Med Chem 48: 5613-38 (2005) Article DOI: 10.1021/jm050524f BindingDB Entry DOI: 10.7270/Q2V988V1 | |||||||||||
More data for this Ligand-Target Pair |