BDBM50179143 (R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((N-isopropylmethan-2-ylsulfonamido)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::CHEMBL381125

SMILES: CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O

InChI Key: InChIKey=WRXWCWIFEFKMJL-ROJLCIKYSA-N

Data: 4 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50179143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC1BR expressed in CHO cells				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	590	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC3R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC1BR by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 5 (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC5R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC4R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 5 (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50179143 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...) Show SMILES CC(C)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)S(C)(=O)=O Show InChI InChI=1S/C35H49ClN4O4S/c1-25(2)40(45(3,43)44)24-35(29-11-5-4-6-12-29)17-19-39(20-18-35)34(42)32(21-26-13-15-30(36)16-14-26)38-33(41)31-22-27-9-7-8-10-28(27)23-37-31/h7-10,13-16,25,29,31-32,37H,4-6,11-12,17-24H2,1-3H3,(H,38,41)/t31-,32-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.60	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Activity against human MC4R by cAMP accumulation				Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S
					More data for this Ligand-Target Pair