BDBM50180258 1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol::CHEMBL197653

SMILES: C[C@H](N)Cn1ncc2ccc(O)c(F)c12

InChI Key: InChIKey=TZBBLWXEAUOTGZ-LURJTMIESA-N

Data: 3 KI  1 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50180258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]DOI from cloned human 5HT2C receptor expressed in CHO cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B) (RAT)	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.10	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50180258 (1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...) Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12 Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
					More data for this Ligand-Target Pair