BDBM50184437 1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine::CHEMBL203734

SMILES: COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl

InChI Key: InChIKey=MYFHADFSNRZMLH-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50184437   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50184437 (1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexah...) Show SMILES COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl Show InChI InChI=1S/C19H21Cl2NO/c1-22-9-7-13-5-3-4-6-14(13)11-16-15(8-10-22)12-17(20)19(23-2)18(16)21/h3-6,12H,7-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Schiller-Universität Jena Curated by ChEMBL					Assay Description Inhibition of D2L dopamine receptor in HEK 293 cells by intracellular calcium assay				J Med Chem 49: 2110-6 (2006) Article DOI: 10.1021/jm051237e BindingDB Entry DOI: 10.7270/Q2ZW1KHD
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50184437 (1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexah...) Show SMILES COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl Show InChI InChI=1S/C19H21Cl2NO/c1-22-9-7-13-5-3-4-6-14(13)11-16-15(8-10-22)12-17(20)19(23-2)18(16)21/h3-6,12H,7-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	25.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Schiller-Universität Jena Curated by ChEMBL					Assay Description Displacement of [3H]SCH 23390 from D1 dopamine receptor				J Med Chem 49: 2110-6 (2006) Article DOI: 10.1021/jm051237e BindingDB Entry DOI: 10.7270/Q2ZW1KHD
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50184437 (1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexah...) Show SMILES COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl Show InChI InChI=1S/C19H21Cl2NO/c1-22-9-7-13-5-3-4-6-14(13)11-16-15(8-10-22)12-17(20)19(23-2)18(16)21/h3-6,12H,7-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Schiller-Universität Jena Curated by ChEMBL					Assay Description Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay				J Med Chem 49: 2110-6 (2006) Article DOI: 10.1021/jm051237e BindingDB Entry DOI: 10.7270/Q2ZW1KHD
					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM50184437 (1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexah...) Show SMILES COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl Show InChI InChI=1S/C19H21Cl2NO/c1-22-9-7-13-5-3-4-6-14(13)11-16-15(8-10-22)12-17(20)19(23-2)18(16)21/h3-6,12H,7-11H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Schiller-Universität Jena Curated by ChEMBL					Assay Description Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay				J Med Chem 49: 2110-6 (2006) Article DOI: 10.1021/jm051237e BindingDB Entry DOI: 10.7270/Q2ZW1KHD
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50184437 (1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexah...) Show SMILES COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl Show InChI InChI=1S/C19H21Cl2NO/c1-22-9-7-13-5-3-4-6-14(13)11-16-15(8-10-22)12-17(20)19(23-2)18(16)21/h3-6,12H,7-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Schiller-Universität Jena Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from D2L dopamine receptor				J Med Chem 49: 2110-6 (2006) Article DOI: 10.1021/jm051237e BindingDB Entry DOI: 10.7270/Q2ZW1KHD
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50184437 (1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexah...) Show SMILES COc1c(Cl)cc2CCN(C)CCc3ccccc3Cc2c1Cl Show InChI InChI=1S/C19H21Cl2NO/c1-22-9-7-13-5-3-4-6-14(13)11-16-15(8-10-22)12-17(20)19(23-2)18(16)21/h3-6,12H,7-11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	415	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Schiller-Universität Jena Curated by ChEMBL					Assay Description Binding affinity to D3 dopamine receptor by radioligand binding assay				J Med Chem 49: 2110-6 (2006) Article DOI: 10.1021/jm051237e BindingDB Entry DOI: 10.7270/Q2ZW1KHD
					More data for this Ligand-Target Pair