BDBM50186374 CHEMBL212049::N-(5-(2-(cyclohexyloxy)-5-methylpyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine

SMILES: Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1

InChI Key: InChIKey=LZCHLXVPHWVKTF-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50186374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50186374 (CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...) Show SMILES Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK7				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50186374 (CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...) Show SMILES Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK9				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50186374 (CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...) Show SMILES Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50186374 (CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...) Show SMILES Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50186374 (CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...) Show SMILES Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK1				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50186374 (CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...) Show SMILES Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 Show InChI InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK5				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
					More data for this Ligand-Target Pair