BDBM50189778 CHEMBL211405::N-tert-butyl-5-amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide::ORG-41841::cid_9887381
SMILES: COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
InChI Key: InChIKey=DVSFSADBOJYPGF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
sentrin-specific protease 1 (Homo sapiens (Human)) | BDBM50189778 (CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2R49PCF | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
sentrin-specific protease 1 (Homo sapiens (Human)) | BDBM50189778 (CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2MC8XNQ | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lutropin-choriogonadotropic hormone receptor (Homo sapiens (Human)) | BDBM50189778 (CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a |
NIH Chemical Genomics Center Curated by ChEMBL | Assay Description Agonist activity at LHCGR (unknown origin) | Medchemcomm 2: 1016-1020 (2011) Article DOI: 10.1039/c1md00145k BindingDB Entry DOI: 10.7270/Q2668H51 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid-stimulating hormone receptor (TSH) (Homo sapiens (Human)) | BDBM50189778 (CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation | J Med Chem 49: 3888-96 (2006) Article DOI: 10.1021/jm060247s BindingDB Entry DOI: 10.7270/Q29886MR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50189778 (CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a |
NIH Chemical Genomics Center Curated by ChEMBL | Assay Description Agonist activity at TSHR (unknown origin) | Medchemcomm 2: 1016-1020 (2011) Article DOI: 10.1039/c1md00145k BindingDB Entry DOI: 10.7270/Q2668H51 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lutropin-choriogonadotropic hormone receptor (Homo sapiens (Human)) | BDBM50189778 (CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation | J Med Chem 49: 3888-96 (2006) Article DOI: 10.1021/jm060247s BindingDB Entry DOI: 10.7270/Q29886MR | |||||||||||
More data for this Ligand-Target Pair |