BDBM50194985 CHEMBL374852::N-(4-(3-chloro-4-fluorophenylamino)-3-cyanoquinolin-6-yl)benzenesulfonamide

SMILES: Fc1ccc(Nc2c(cnc3ccc(NS(=O)(=O)c4ccccc4)cc23)C#N)cc1Cl

InChI Key: InChIKey=JOTYJHPYNCTWBJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194985   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50194985 (CHEMBL374852 | N-(4-(3-chloro-4-fluorophenylamino)...) Show SMILES Fc1ccc(Nc2c(cnc3ccc(NS(=O)(=O)c4ccccc4)cc23)C#N)cc1Cl Show InChI InChI=1S/C22H14ClFN4O2S/c23-19-11-15(6-8-20(19)24)27-22-14(12-25)13-26-21-9-7-16(10-18(21)22)28-31(29,30)17-4-2-1-3-5-17/h1-11,13,28H,(H,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair