BindingDB logo
myBDB logout

BDBM50201394 CHEMBL393779::N-(4-tert-butylphenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide

SMILES: Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=GRWWMWQTKFKHLE-UHFFFAOYSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50201394   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201394
PNG
(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)18-19(24-14-26(18)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.200n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by [32P]ATP-competitive radioassay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201394
PNG
(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)18-19(24-14-26(18)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201394
PNG
(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)18-19(24-14-26(18)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201394
PNG
(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)18-19(24-14-26(18)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair