BDBM50207478 CHEMBL223572::N-{4-[3-amino-7-(4-morpholinylmethyl)-1H-indazol-4-yl]phenyl}-N'-(3-methylphenyl)urea

SMILES: Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1

InChI Key: InChIKey=TWVXVSDWFBDEBO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50207478   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207478 (CHEMBL223572 | N-{4-[3-amino-7-(4-morpholinylmethy...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H28N6O2/c1-17-3-2-4-21(15-17)29-26(33)28-20-8-5-18(6-9-20)22-10-7-19(16-32-11-13-34-14-12-32)24-23(22)25(27)31-30-24/h2-10,15H,11-14,16H2,1H3,(H3,27,30,31)(H2,28,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207478 (CHEMBL223572 | N-{4-[3-amino-7-(4-morpholinylmethy...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H28N6O2/c1-17-3-2-4-21(15-17)29-26(33)28-20-8-5-18(6-9-20)22-10-7-19(16-32-11-13-34-14-12-32)24-23(22)25(27)31-30-24/h2-10,15H,11-14,16H2,1H3,(H3,27,30,31)(H2,28,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207478 (CHEMBL223572 | N-{4-[3-amino-7-(4-morpholinylmethy...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(CN3CCOCC3)c3[nH]nc(N)c23)c1 Show InChI InChI=1S/C26H28N6O2/c1-17-3-2-4-21(15-17)29-26(33)28-20-8-5-18(6-9-20)22-10-7-19(16-32-11-13-34-14-12-32)24-23(22)25(27)31-30-24/h2-10,15H,11-14,16H2,1H3,(H3,27,30,31)(H2,28,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair