BDBM50207493 1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-m-tolylurea::CHEMBL219998::N-[4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)urea

SMILES: COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12

InChI Key: InChIKey=MUUMAOMIQCDWLM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207493   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207493 (1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...) Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207493 (1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...) Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Punjabi University Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF method				Eur J Med Chem 45: 393-404 (2010) Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207493 (1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...) Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207493 (1-(4-(3-amino-7-methoxy-1H-indazol-4-yl)phenyl)-3-...) Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C22H21N5O2/c1-13-4-3-5-16(12-13)25-22(28)24-15-8-6-14(7-9-15)17-10-11-18(29-2)20-19(17)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair