Found 4 hits for monomerid = 50207502 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50207502
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12 Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50207502
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12 Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Punjabi University
Curated by ChEMBL
| Assay Description Inhibition of c-Kit by HTRF method |
Eur J Med Chem 45: 393-404 (2010)
Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50207502
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12 Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of FLT3 by HTRF assay |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50207502
(1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-hydroxy...)Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(O)c4)cc3)c12 Show InChI InChI=1S/C20H17N5O2/c21-19-18-16(5-2-6-17(18)24-25-19)12-7-9-13(10-8-12)22-20(27)23-14-3-1-4-15(26)11-14/h1-11,26H,(H3,21,24,25)(H2,22,23,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of c-Kit by HTRF assay |
J Med Chem 50: 1584-97 (2007)
Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95 |
More data for this Ligand-Target Pair | |