BDBM50209158 2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen-3-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-acetamide::CHEMBL245377

SMILES: CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1

InChI Key: InChIKey=OPPRLSONSGULSP-UHFFFAOYSA-N

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50209158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Lyn by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of CSF1R by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Src by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Hck by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Fyn by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Tie2 by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Flt1 by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Flt3 by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Lck by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair