null
SMILES: O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1
InChI Key: InChIKey=JKJMWHULJIOKPJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol lipase-alpha (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs... | J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoacylglycerol lipase ABHD6 (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of human ABHD6 using 2-AG as natural substrate by fluorescence based assay | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-beta (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of HT-01 probe binding to recombinant mouse DAGLbeta expressed in HEK293T cell membrane proteomes preincubated for 30 mins followed by HT-... | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of HT-01 probe binding to recombinant human DAGLalpha expressed in HEK293T cell membrane proteomes preincubated for 30 mins followed by HT... | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-beta (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of recombinant mouse DAGLbeta expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte... | J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-beta (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincuba... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-beta (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincuba... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-beta (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-beta (Mus musculus) | BDBM50211236 (CHEMBL2144065) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad... | Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of HT-01 probe binding to recombinant human DAGLalpha expressed in HEK293T cell membrane proteomes preincubated for 30 mins followed by HT... | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol lipase-alpha (Homo sapiens (Human)) | BDBM50211236 (CHEMBL2144065) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s... | J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79 | |||||||||||
More data for this Ligand-Target Pair |