Compile Data Set for Download or QSAR

Found 420 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol lipase-alpha'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50519345 (CHEMBL4447844) Show SMILES Cc1ccc(cc1)-c1cnc2nc(oc2c1)C(=O)CCCCCc1ccccc1 Show InChI InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211257 (CHEMBL3895863 | US10583137, Compound 14) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211236 (CHEMBL2144065) Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211265 (CHEMBL3954476) Show SMILES OC(c1cnn(n1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-19-31-34(32-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2/t25-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50519341 (CHEMBL4437021) Show SMILES OC(c1cn(nn1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-19-34(32-31-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2/t25-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	339	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50048620 (CHEMBL3319620) Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human DAGLalpha expressed in HEK293T cell membranes assessed as reduction in hydrolysis of inhibition of [14C]-sn-1-oleoyl-2-arachidono...				J Med Chem 57: 6610-22 (2014) Article DOI: 10.1021/jm500681z BindingDB Entry DOI: 10.7270/Q2R49SD4
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50519343 (CHEMBL4572363) Show SMILES OC(c1ccn(n1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C29H27F2N3O2/c30-24-13-9-22(10-14-24)29(36,23-11-15-25(31)16-12-23)27-17-19-34(32-27)28(35)33-18-5-4-8-26(33)20-21-6-2-1-3-7-21/h1-3,6-7,9-17,19,26,36H,4-5,8,18,20H2/t26-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50519342 (CHEMBL4532055) Show SMILES OC(c1ncn(n1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-31-19-34(32-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2/t25-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes assessed as inhibition constant pre-incubated for 20 mins before PNP-butyrate subs...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50532882 (CHEMBL4476210) Show SMILES CCCCCCCCCCCC(C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24?,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50532882 (CHEMBL4476210) Show SMILES CCCCCCCCCCCC(C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24?,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50532882 (CHEMBL4476210) Show SMILES CCCCCCCCCCCC(C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24?,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50532882 (CHEMBL4476210) Show SMILES CCCCCCCCCCCC(C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24?,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM434879 (US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...) Show SMILES CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.501	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM434879 (US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...) Show SMILES CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.501	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148158 (CHEMBL3764017) Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C29H29Cl2NO5S/c1-28(2)12-9-20-16-25(7-8-26(20)37-28)38(35,36)32(18-27(33)34)29(10-4-11-29)22-6-3-5-19(13-22)21-14-23(30)17-24(31)15-21/h3,5-8,13-17H,4,9-12,18H2,1-2H3,(H,33,34)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211257 (CHEMBL3895863 | US10583137, Compound 14) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.631	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211240 (CHEMBL3897587) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC1CC1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C32H32F2N4O3/c33-26-12-8-24(9-13-26)32(40,25-10-14-27(34)15-11-25)30-19-35-38(36-30)31(39)37-20-29(41-21-23-6-7-23)17-16-28(37)18-22-4-2-1-3-5-22/h1-5,8-15,19,23,28-29,40H,6-7,16-18,20-21H2/t28-,29-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.631	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211271 (CHEMBL3913807) Show SMILES CO[C@@H]1CC[C@H](Cc2ccccc2)N(C1)C(=O)n1ncc(n1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C29H28F2N4O3/c1-38-26-16-15-25(17-20-5-3-2-4-6-20)34(19-26)28(36)35-32-18-27(33-35)29(37,21-7-11-23(30)12-8-21)22-9-13-24(31)14-10-22/h2-14,18,25-26,37H,15-17,19H2,1H3/t25-,26-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.794	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211266 (CHEMBL3906477) Show SMILES O=C(N1CCCC[C@@H]1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2/t25-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.794	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211265 (CHEMBL3954476) Show SMILES OC(c1cnn(n1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-19-31-34(32-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2/t25-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.794	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148192 (CHEMBL3765578) Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)C1(CCCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C30H31Cl2NO5S/c1-29(2)13-10-21-17-26(8-9-27(21)38-29)39(36,37)33(19-28(34)35)30(11-3-4-12-30)23-7-5-6-20(14-23)22-15-24(31)18-25(32)16-22/h5-9,14-18H,3-4,10-13,19H2,1-2H3,(H,34,35)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211269 (CHEMBL3970032) Show SMILES OC(c1cnn(n1)C(=O)N1CCCCC1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-19-31-34(32-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211257 (CHEMBL3895863 | US10583137, Compound 14) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM24567 ((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...) Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of human recombinant DAGLalpha expressed in African green monkey COS cells using sn-1-stearoyl-2-[14C]-arachidonoyl-glycerol as substrate ...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211236 (CHEMBL2144065) Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211257 (CHEMBL3895863 | US10583137, Compound 14) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211257 (CHEMBL3895863 | US10583137, Compound 14) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211257 (CHEMBL3895863 | US10583137, Compound 14) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC#C)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H28F2N4O3/c1-2-18-40-28-17-16-27(19-22-6-4-3-5-7-22)36(21-28)30(38)37-34-20-29(35-37)31(39,23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h1,3-15,20,27-28,39H,16-19,21H2/t27-,28-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211240 (CHEMBL3897587) Show SMILES OC(c1cnn(n1)C(=O)N1C[C@@H](CC[C@@H]1Cc1ccccc1)OCC1CC1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C32H32F2N4O3/c33-26-12-8-24(9-13-26)32(40,25-10-14-27(34)15-11-25)30-19-35-38(36-30)31(39)37-20-29(41-21-23-6-7-23)17-16-28(37)18-22-4-2-1-3-5-22/h1-5,8-15,19,23,28-29,40H,6-7,16-18,20-21H2/t28-,29-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211271 (CHEMBL3913807) Show SMILES CO[C@@H]1CC[C@H](Cc2ccccc2)N(C1)C(=O)n1ncc(n1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C29H28F2N4O3/c1-38-26-16-15-25(17-20-5-3-2-4-6-20)34(19-26)28(36)35-32-18-27(33-35)29(37,21-7-11-23(30)12-8-21)22-9-13-24(31)14-10-22/h2-14,18,25-26,37H,15-17,19H2,1H3/t25-,26-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211260 (CHEMBL3964338) Show SMILES OC(c1cnn(n1)C(=O)N1CCCCC1Cc1ccccc1)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C28H28N4O2/c33-27(31-19-11-10-18-25(31)20-22-12-4-1-5-13-22)32-29-21-26(30-32)28(34,23-14-6-2-7-15-23)24-16-8-3-9-17-24/h1-9,12-17,21,25,34H,10-11,18-20H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50519345 (CHEMBL4447844) Show SMILES Cc1ccc(cc1)-c1cnc2nc(oc2c1)C(=O)CCCCCc1ccccc1 Show InChI InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148188 (CHEMBL3763826) Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1cccc(c1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C26H25Cl2NO5S/c1-26(2)9-8-19-13-23(6-7-24(19)34-26)35(32,33)29(16-25(30)31)15-17-4-3-5-18(10-17)20-11-21(27)14-22(28)12-20/h3-7,10-14H,8-9,15-16H2,1-2H3,(H,30,31)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148184 (CHEMBL3763853) Show SMILES OC(=O)CN(Cc1cccc(c1)-c1cccc(Cl)c1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C22H17Cl2F2NO5S/c23-19-6-2-5-18(21(19)24)15-4-1-3-14(11-15)12-27(13-20(28)29)33(30,31)17-9-7-16(8-10-17)32-22(25)26/h1-11,22H,12-13H2,(H,28,29)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50211265 (CHEMBL3954476) Show SMILES OC(c1cnn(n1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-19-31-34(32-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2/t25-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148193 (CHEMBL3765716) Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C26H25Cl2NO5S/c1-26(2)10-9-19-13-23(7-8-24(19)34-26)35(32,33)29(16-25(30)31)15-17-3-5-18(6-4-17)20-11-21(27)14-22(28)12-20/h3-8,11-14H,9-10,15-16H2,1-2H3,(H,30,31)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50519345 (CHEMBL4447844) Show SMILES Cc1ccc(cc1)-c1cnc2nc(oc2c1)C(=O)CCCCCc1ccccc1 Show InChI InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50519345 (CHEMBL4447844) Show SMILES Cc1ccc(cc1)-c1cnc2nc(oc2c1)C(=O)CCCCCc1ccccc1 Show InChI InChI=1S/C25H24N2O2/c1-18-12-14-20(15-13-18)21-16-23-24(26-17-21)27-25(29-23)22(28)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-17H,3,6-7,10-11H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211233 (CHEMBL3941507) Show SMILES COc1cccc(CC2CCCCN2C(=O)n2ncc(n2)C(O)(c2ccc(F)cc2)c2ccc(F)cc2)c1 Show InChI InChI=1S/C29H28F2N4O3/c1-38-26-7-4-5-20(18-26)17-25-6-2-3-16-34(25)28(36)35-32-19-27(33-35)29(37,21-8-12-23(30)13-9-21)22-10-14-24(31)15-11-22/h4-5,7-15,18-19,25,37H,2-3,6,16-17H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50161525 (1-(oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one...) Show SMILES O=C(CCCCCCCCc1ccccc1)c1nc2ncccc2o1 Show InChI InChI=1S/C21H24N2O2/c24-18(21-23-20-19(25-21)15-10-16-22-20)14-9-4-2-1-3-6-11-17-12-7-5-8-13-17/h5,7-8,10,12-13,15-16H,1-4,6,9,11,14H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay				J Med Chem 58: 9742-53 (2015) Article DOI: 10.1021/acs.jmedchem.5b01627 BindingDB Entry DOI: 10.7270/Q2D50QZ9
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Mus musculus)	BDBM50519341 (CHEMBL4437021) Show SMILES OC(c1cn(nn1)C(=O)N1CCCC[C@@H]1Cc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H26F2N4O2/c29-23-13-9-21(10-14-23)28(36,22-11-15-24(30)16-12-22)26-19-34(32-31-26)27(35)33-17-5-4-8-25(33)18-20-6-2-1-3-7-20/h1-3,6-7,9-16,19,25,36H,4-5,8,17-18H2/t25-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...				J Med Chem 62: 7910-7922 (2019) Article DOI: 10.1021/acs.jmedchem.9b00686 BindingDB Entry DOI: 10.7270/Q2GQ724G
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50532882 (CHEMBL4476210) Show SMILES CCCCCCCCCCCC(C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24?,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50532882 (CHEMBL4476210) Show SMILES CCCCCCCCCCCC(C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24?,25-,26-,27-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...				Bioorg Med Chem Lett 26: 3831-7 (2016) Article DOI: 10.1016/j.bmcl.2016.06.076 BindingDB Entry DOI: 10.7270/Q20C508W
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148154 (CHEMBL3763831) Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1cc(Cl)cc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H20Cl3NO4S/c25-19-5-7-22(8-6-19)33(31,32)28(15-23(29)30)24(9-2-10-24)18-4-1-3-16(11-18)17-12-20(26)14-21(27)13-17/h1,3-8,11-14H,2,9-10,15H2,(H,29,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211277 (CHEMBL3903742) Show SMILES COc1ccc(CC2CCCCN2C(=O)n2ncc(n2)C(O)(c2ccc(F)cc2)c2ccc(F)cc2)cc1 Show InChI InChI=1S/C29H28F2N4O3/c1-38-26-15-5-20(6-16-26)18-25-4-2-3-17-34(25)28(36)35-32-19-27(33-35)29(37,21-7-11-23(30)12-8-21)22-9-13-24(31)14-10-22/h5-16,19,25,37H,2-4,17-18H2,1H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211274 (CHEMBL3916842) Show SMILES OC(c1cnn(n1)C(=O)N1CCCCC1COc1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 Show InChI InChI=1S/C28H26F2N4O3/c29-22-13-9-20(10-14-22)28(36,21-11-15-23(30)16-12-21)26-18-31-34(32-26)27(35)33-17-5-4-6-24(33)19-37-25-7-2-1-3-8-25/h1-3,7-16,18,24,36H,4-6,17,19H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211256 (CHEMBL3921538) Show SMILES OC(c1cnn(n1)C(=O)N1CCCCC1COc1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 Show InChI InChI=1S/C28H25F3N4O3/c29-21-8-4-19(5-9-21)28(37,20-6-10-22(30)11-7-20)26-17-32-35(33-26)27(36)34-16-2-1-3-24(34)18-38-25-14-12-23(31)13-15-25/h4-15,17,24,37H,1-3,16,18H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50148187 (CHEMBL3764093) Show SMILES OC(=O)CN(C1(CCC1)c1cccc(c1)-c1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H19Cl4NO4S/c25-17-5-7-19(21(27)12-17)15-3-1-4-16(11-15)24(9-2-10-24)29(14-23(30)31)34(32,33)18-6-8-20(26)22(28)13-18/h1,3-8,11-13H,2,9-10,14H2,(H,30,31)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...				Bioorg Med Chem 24: 1455-68 (2016) Article DOI: 10.1016/j.bmc.2016.02.006 BindingDB Entry DOI: 10.7270/Q2RJ4MBD
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211273 (CHEMBL3986579) Show SMILES OC(c1cnn(n1)C(=O)N1CCCCC1COc1ccc(F)cc1)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C28H27FN4O3/c29-23-14-16-25(17-15-23)36-20-24-13-7-8-18-32(24)27(34)33-30-19-26(31-33)28(35,21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-6,9-12,14-17,19,24,35H,7-8,13,18,20H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair
Diacylglycerol lipase-alpha (Homo sapiens (Human))	BDBM50211236 (CHEMBL2144065) Show SMILES O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Leiden University Curated by ChEMBL					Assay Description Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay				J Med Chem 60: 428-440 (2017) Article DOI: 10.1021/acs.jmedchem.6b01482 BindingDB Entry DOI: 10.7270/Q28K7C79
					More data for this Ligand-Target Pair

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