BDBM50212458 CHEMBL132656

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc\c2=N/C1CC1)C1CC1

InChI Key: InChIKey=WBRAPOAOVMYUAP-LGUFXXKBSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50212458 (CHEMBL132656) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc\c2=N/C1CC1)C1CC1 Show InChI InChI=1S/C22H21F2N3/c1-12-9-14(10-13(2)25-12)20-18(23)11-17-19(26-15-3-4-15)7-8-27(16-5-6-16)22(17)21(20)24/h7-11,15-16H,3-6H2,1-2H3/b26-19+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.				Citation and Details BindingDB Entry DOI: 10.7270/Q2R49SXV
					More data for this Ligand-Target Pair