BDBM50215796 CHEMBL400057::N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(dimethylamino)pyrimidin-4-yl)methylamino)benzamide

SMILES: CN(C)c1nccc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)n1

InChI Key: InChIKey=ROESLTYJYYWMJD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50215796   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50215796 (CHEMBL400057 | N-(2,2-difluorobenzo[d][1,3]dioxol-...) Show SMILES CN(C)c1nccc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)n1 Show InChI InChI=1S/C21H19F2N5O3/c1-28(2)20-24-10-9-14(27-20)12-25-16-6-4-3-5-15(16)19(29)26-13-7-8-17-18(11-13)31-21(22,23)30-17/h3-11,25H,12H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant cKit by FRET assay				Bioorg Med Chem Lett 17: 4378-81 (2007) Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50215796 (CHEMBL400057 | N-(2,2-difluorobenzo[d][1,3]dioxol-...) Show SMILES CN(C)c1nccc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)n1 Show InChI InChI=1S/C21H19F2N5O3/c1-28(2)20-24-10-9-14(27-20)12-25-16-6-4-3-5-15(16)19(29)26-13-7-8-17-18(11-13)31-21(22,23)30-17/h3-11,25H,12H2,1-2H3,(H,26,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	349	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of b-Raf				Bioorg Med Chem Lett 17: 4378-81 (2007) Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7
					More data for this Ligand-Target Pair