BDBM50222303 4',6,7,-trihydroxyisoflavone::4',6,7-trihydroxyisoflavone::6,7,3'-trihydroxyisoflavone::6,7,4'-trihydroxyisoflavone::6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one::CHEMBL239156::IR-1
SMILES: Oc1ccc(cc1)-c1coc2cc(O)c(O)cc2c1=O
InChI Key: InChIKey=GYLUFQJZYAJQDI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
15-Lipoxygenase-2 (15-LOX-2) (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Universidad de Santiago | Assay Description The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a... | Chem Biol Drug Des 86: 114-21 (2015) Article DOI: 10.1111/cbdd.12469 BindingDB Entry DOI: 10.7270/Q2PZ57JF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Universidad de Santiago | Assay Description The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a... | Chem Biol Drug Des 86: 114-21 (2015) Article DOI: 10.1111/cbdd.12469 BindingDB Entry DOI: 10.7270/Q2PZ57JF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
15-Lipoxygenase-2 (15-LOX-2) (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Santiago de Chile Curated by ChEMBL | Assay Description Inhibition of 15-hLO2 | Bioorg Med Chem 15: 7408-25 (2007) Article DOI: 10.1016/j.bmc.2007.07.036 BindingDB Entry DOI: 10.7270/Q2RN37KN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 15-lipoxygenase (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Santiago de Chile Curated by ChEMBL | Assay Description Inhibition of 15-hLO1 | Bioorg Med Chem 15: 7408-25 (2007) Article DOI: 10.1016/j.bmc.2007.07.036 BindingDB Entry DOI: 10.7270/Q2RN37KN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Topoisomerase I/II (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.62E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Inhibition of human DNA topoisomerase 2 catalytic domain-mediated knotted bacteriophage P4Virl dell0 DNA unknotting by agarose gel electrophoresis | J Nat Prod 58: 217-25 (1995) Article DOI: 10.1021/np50116a009 BindingDB Entry DOI: 10.7270/Q2SQ936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation Curated by ChEMBL | Assay Description Inhibition of xanthine oxidase (unknown origin) assessed as decrease of superoxide generation | Bioorg Med Chem Lett 18: 5006-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.016 BindingDB Entry DOI: 10.7270/Q2QF8SQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation Curated by ChEMBL | Assay Description Inhibition of xanthine oxidase (unknown origin) assessed as decrease of uric acid generation | Bioorg Med Chem Lett 18: 5006-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.016 BindingDB Entry DOI: 10.7270/Q2QF8SQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosinase (Mus musculus (Mouse)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AmorePacific Corporation Curated by ChEMBL | Assay Description Inhibition of tyrosinase in mouse Melan-a cells by ELISA | Bioorg Med Chem Lett 20: 1162-4 (2010) Article DOI: 10.1016/j.bmcl.2009.12.021 BindingDB Entry DOI: 10.7270/Q2M045JZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
12-Lipoxygenase (12-LOX) (Homo sapiens (Human)) | BDBM50222303 (4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Santiago de Chile Curated by ChEMBL | Assay Description Inhibition of 12-hLO | Bioorg Med Chem 15: 7408-25 (2007) Article DOI: 10.1016/j.bmc.2007.07.036 BindingDB Entry DOI: 10.7270/Q2RN37KN | |||||||||||
More data for this Ligand-Target Pair |