BDBM50227758 3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid::CHEMBL399417
SMILES: Cc1cc(Oc2cccc(CNC(=O)c3cc4cc(Cl)ccc4n3C)c2)ccc1CCC(O)=O
InChI Key: InChIKey=LCOLZKUTZKYABX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peroxisome proliferator-activated receptor (Homo sapiens (Human)) | BDBM50227758 (3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 135 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Agonist activity at human PPARgamma expressed in CV1 cells by receptor transactivation assay | Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human)) | BDBM50227758 (3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamid...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 87 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Agonist activity at human PPARdelta expressed in CV1 cells by receptor transactivation assay | Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor delta (Homo sapiens (Human)) | BDBM50227758 (3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamid...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdelta | Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human)) | BDBM50227758 (3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamid...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Agonist activity at human PPARalpha expressed in CV1 cells by receptor transactivation assay | Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor (Homo sapiens (Human)) | BDBM50227758 (3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-2-methyl-2-(4-{3-{propyl-(5-pyridin-2-yl-thiophene-2-sulfonyl)-amino}-propyl}-phenoxy)-propionic acid from human PPARgamma | Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor alpha (PPAR alpha) (Homo sapiens (Human)) | BDBM50227758 (3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamid...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARalpha | Bioorg Med Chem Lett 17: 6744-9 (2008) Article DOI: 10.1016/j.bmcl.2007.10.047 BindingDB Entry DOI: 10.7270/Q2VT1RTW | |||||||||||
More data for this Ligand-Target Pair |