BDBM50229242 CHEMBL4084908

SMILES: CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1

InChI Key: InChIKey=OCPQFPCBYIDUNI-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229242   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50229242 (CHEMBL4084908) Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1 Show InChI InChI=1S/C16H20F3NO/c1-16(6-4-3-5-7-16)15(21)20(2)10-11-8-12(17)9-13(18)14(11)19/h8-9H,3-7,10H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair